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| Typical applications of Bredereck's reagent（CAS:5815-08-7）（4） |
| 2022-06-19 |
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To a solution of ketones 13b-d (1.3 mmol) in anhydrous DMF (2.5 mL),
TBDMAM(CAS:5815-08-7, tert-Butoxy bis(dimethylamino)methane) (0.41 mL, 2 mmol) was added
and the reaction mixture was irradiated under microwave conditions(Power 50 W; Pressure 100 psi; Temperature 100 C) up to completeness (TLC).
In both cases, the reaction mixtures was poured onto crushedice.
The precipitate was filtered off and dried, in the absence ofprecipitate the solution was extracted with AcOEt (3 30 mL).
The organic layer was dried (Na2SO4) and the solvent was removedunder reduced pressure.
Ref:[European Journal of Medicinal Chemistry, 2016, vol. 123, p. 447 - 461]
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