Download our new 2011 product
catalog online: |
 PDF file |  Excel file | SDF file |
|
| Typical applications of Bredereck's reagent（CAS:5815-08-7）（7） |
| 2022-06-20 |
|
|
Methyl (E)-2-[2-(Dimethylamino)vinyl]-4-methoxy-5-nitrobenzoate (12)
A mixture of methyl 4-methoxy-2-methyl-5-nitrobenzoate (11) (3.0 g, 13.32 mmol)
and 1-tert-butoxy-N,N,N′,N′-tetramethylmethanediamine (3.3 mL, 15.99 mmol) was heated at 115 °C (no solvent) for 3.5h.
After cooling to r.t., the mixture was triturated with EtOAc/hexanes (1:6).
The solid compound was collected by filtration and dried to provide of methyl (E)-2-[2-(dimethylamino)vinyl]-4-methoxy-5-nitrobenzoate (12) (3.6 g (96%) as an orange colored solid;
mp 160-163 °C.
Ref: [Synthesis, 2017, vol. 49, # 12, p. 2768 - 2774]
|
|
